Ultiros 10

Each film-coated tablet contains:

Rosuvastatin Calcium equivalent to Rosuvastatin….10 mg

Ultiros 20

Each film-coated tablet contains:

Rosuvastatin Calcium equivalent to Rosuvastatin…20 mg

Tablet

Rosuvastatin is a selective and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme that converts HMG-CoA to mevalonate, a precursor of cholesterol. In vivo studies in animals and in vitro studies in cultured animal and human cells have shown rosuvastatin to have a high uptake into, and selectivity for, action in the liver, the target organ for cholesterol lowering. In in vivo and in vitro studies, rosuvastatin produces its lipid-modifying effects in two ways. First, it increases the number of hepatic low-density lipoprotein (LDL) receptors on the cell-surface to enhance uptake and catabolism of LDL. Second, rosuvastatin inhibits hepatic synthesis of very-low-density lipoprotein (VLDL), which reduces the total number of VLDL and LDL particles.

Rosuvastatin reduces elevated LDL-cholesterol (LDL-C), total-cholesterol (total-C) and triglycerides (TG) and increases high-density lipoprotein-cholesterol (HDL-C). It also lowers apolipoprotein (Apo) B, non-HDL-C, VLDL-cholesterol (VLDL-C), VLDL-TG and increases ApoA1. Rosuvastatin also lowers the LDL-C/HDL-C, total-C/HDL-C and non-HDL-C/HDL-C and the ApoB/ApoA1 ratios.

Ultiros 10: Strip of 10 tablets

Ultiros 20: Strip of 10 tablets